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Remodeled DLBCL frequently insert CDKN2A deletions and MYC translocations or amplifications in addition to the genomic alterations currently present in the first CLL, but absence the typical mutations observed in Main DLBCL indicating they may SITUS JUDI MBL77 possibly correspond to another biological classification.eighty Richter transformation also takes place in clients treated with BTK inhibitors. These tumors tend not to usually receive BTK or PLCG2 mutations but, if these were present in the original CLL, subclones may possibly arise with supplemental independent mutations.89,90
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